李志衍;赵婷婷;曹玉颖;张希墨;邱基程;郭燕莹;李淑媛;张璐;龚晓会;吴琴尧;曹兴元;

• 1:北京市畜牧总站
• 2:中国农业大学动物医学院
• 3:国家兽药安全评价中心

摘要(Abstract)：

为了研究阿莫西林-克拉维酸钾可溶性粉在猪体内的药代动力学特征,笔者以12.5 mg/kg·bw剂量单次给猪灌服阿莫西林-克拉维酸钾可溶性粉,于给药前和给药后特定时间点采集血浆样品,采用UPLC-MS/MS法测定血浆药物浓度,并使用WinNonlin R 8.1软件进行非房室模型分析。内服给药后,阿莫西林和克拉维酸的T1/2无显著差异(分别为1.14±0.24 h和1.32±0.29 h),二者的Cmax分别为2.58±0.67μg/mL和1.91±0.28μg/mL,Tmax分别为1.67±0.34 h和1.46±0.10 h,AUClast分别为7.33±1.80 mg·h/L和4.98±0.67 mg·h/L。阿莫西林和克拉维酸的平均内服生物利用度分别为23.0%和26.4%。试验结果说明,本研究建立的检测方法灵敏度高、干扰少,适用于猪血浆中阿莫西林-克拉维酸钾的检测;药代动力学研究表明2种药代谢快,在猪体内的停留时间较短。

关键词(KeyWords)： 阿莫西林;克拉维酸;猪;UPLC-MS/MS;药代动力学

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 李志衍;赵婷婷;曹玉颖;张希墨;邱基程;郭燕莹;李淑媛;张璐;龚晓会;吴琴尧;曹兴元;

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